NONACCIDENTAL ENDOSULFAN INTOXICATION - A CASE-REPORT WITH TOXICOKINETIC CALCULATIONS AND TISSUE CONCENTRATIONS

Case Report: A case of nonaccidental endosulfan intoxication in a prev iously healthy 43-year-old male patient is reported. On admission, the patient had few symptoms, but refractory seizures began 1 hour after ingestion. The patient died on the fourth day after admission showing clinical signs of cerebral herniation confirmed at autopsy. Blood, uri ne, and tissue samples were analyzed for alpha-endosulfan, beta-endosu lfan, and endosulfan sulfate by capillary gas chromatography with elec tron capture detection. Concentration versus time data for endosulfan were fitted using the program MW/Pharm(R), assuming complete bioavaila bility although it is recognized that the bioavailability of endosulfa n after ingestion may have been low and the calculated clearance was p rimarily due to redistribution. Hemoperfusion was shown to be ineffect ive.