INVOLVEMENT OF NITRIC-OXIDE IN NORADRENALINE-INDUCED INCREASE IN BLOOD-FLOW THROUGH BROWN ADIPOSE-TISSUE

Authors
NAGASHIMA T OHINATA H KUROSHIMA A
Citation
T. Nagashima et al., INVOLVEMENT OF NITRIC-OXIDE IN NORADRENALINE-INDUCED INCREASE IN BLOOD-FLOW THROUGH BROWN ADIPOSE-TISSUE, Life sciences, 54(1), 1994, pp. 17-25
Citations number
16
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
1
Year of publication
1994
Pages
17 - 25
Database
ISI
SICI code
0024-3205(1994)54:1<17:IONINI>2.0.ZU;2-8
Abstract
N(omega)-nitro-L-arginine methyl ester (L-NAME) (80 mg), a NO synthase blocker, completely abolished noradrenaline (NA)-induced increase in blood flow through brown adipose tissue (BAT) in the urethan-anestheti zed rat. L-NAME suppressed NA-induced increase in blood flow dose-depe ndently. L-arginine (80 mg), but not D-arginine (80 mg), reversed the inhibitory effect of L-NAME (0.8 mg). NA-induced increase in BAT tempe rature was also decreased by L-NAME. These results suggest that nitric oxide mediates NA-induced increase in BAT blood flow.