DRUGS FOR CHIRAL DISCRIMINATION - NON-CODED AMINO-ACIDS AND DIPEPTIDES BY ASYMMETRIC HYDROGENATION

Authors
KREUZFELD HJ DOBLER C SCHMIDT U KRAUSE HW
Citation
Hj. Kreuzfeld et al., DRUGS FOR CHIRAL DISCRIMINATION - NON-CODED AMINO-ACIDS AND DIPEPTIDES BY ASYMMETRIC HYDROGENATION, Chirality, 10(6), 1998, pp. 535-539
Citations number
18
Categorie Soggetti
Chemistry Medicinal","Chemistry Analytical","Chemistry Inorganic & Nuclear","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
10
Issue
6
Year of publication
1998
Pages
535 - 539
Database
ISI
SICI code
0899-0042(1998)10:6<535:DFCD-N>2.0.ZU;2-L
Abstract
The enantiomers of Propranolol, Pindolol, and Carazolol, well-known be ta-blockers, have been used to prepare cationic aminophosphine phosphi nite rhodium complexes. Propraphos-Rh and Pindophos-Rh are very effici ent catalysts in the asymmetric hydrogenation of N-Boc-protected unusu al dehydroamino acid derivatives. Carazolol-Rh is less suitable in bot h activity and enantioselectivity. Under the same conditions, N-Boc-pr otected dehydrodipeptides are hydrogenated with diastereoselectivities between 70 and 90% de. Chirality 10:535-539, 1998. (C) 1998 Wiley-Lis s, Inc.