IN-VITRO ACTIVITY OF VORICONAZOLE AGAINST SELECTED FUNGI

Fifty-nine isolates consisting of 14 genera and 33 species of ascomyce tes, basidiomycetes, and zygomycetes were tested against amphotericin B, fluconazole, itraconazole and voriconazole using an in vitro modifi ed macrobroth dilution procedure based upon the NCCLS M27-A standard m ethod for yeasts. The triazoles voriconazole and itraconazole had simi lar MIC values, except for Acremonium alabamensis, A. strictum, Fusari um oxysporum, F. solani and Wangiella dermatitidis, which had substant ially lower voriconazole MIC values. Voriconazole MIC values were lowe r than those for itraconazole for the 17 species of Trichosporon teste d. Fluconazole had high MIC values, often greater than 128 mu g ml(-1) .