IN-VITRO EVALUATION OF TERBINAFINE AND ITRACONAZOLE AGAINST DEMATIACEOUS FUNGI

Two hundred and three isolates representing 15 species of filamentous ascomycetes were evaluated against terbinafine and itraconazole using a modification of the NCCLS M27-A standard reference method for yeasts . The MIC ranges and geometric means were similar, although terbinafin e tended to have the lowest values. The loculoascomycete clade tested had consistently low MIC geometric mean values for its members, rangin g from 0.03 to 0.17 mu g ml(-1) for terbinafine and 0.03-0.37 mu g ml( -1) for itraconazole.