THE GALLIUM-DEFEROXAMINE COMPLEX - STABILITY WITH DIFFERENT DEFEROXAMINE CONCENTRATIONS AND INCUBATION CONDITIONS

Authors
CARACO C ALOJ L ECKELMAN WC
Citation
C. Caraco et al., THE GALLIUM-DEFEROXAMINE COMPLEX - STABILITY WITH DIFFERENT DEFEROXAMINE CONCENTRATIONS AND INCUBATION CONDITIONS, Applied radiation and isotopes, 49(12), 1998, pp. 1477-1479
Citations number
12
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
49
Issue
12
Year of publication
1998
Pages
1477 - 1479
Database
ISI
SICI code
0969-8043(1998)49:12<1477:TGC-SW>2.0.ZU;2-0
Abstract
Previous studies report that deferoxamine (DFO) binds metallic ions su ch as Fe3+, In3+ and Ga3+ with very high affinity. This property of DF O has been utilized to label DFO-coupled compounds with radiometals su ch as Ga-67 and In-111. We have studied the effect of low DFO concentr ations and of different incubation conditions on the stability of the Ga-67-DFO complex. In our experience high (>5 mu M) DFO concentration appears to be critical in obtaining high radiochemical purity of such complexes. (C) 1998 Elsevier Science Ltd. All rights reserved.