RADIOCHEMICAL PURIFICATION OF NO-CARRIER-ADDED SC-47 FOR RADIOIMMUNOTHERAPY

A procedure, adaptable to large-scale remote operation, was developed to purify no-carrier-added (NCA) (SC)-S-47 from irradiated Ti targets. Methods based on extraction chromatography and cation-exchange chroma tography were compared. Results of this comparison led to the developm ent of an optimized procedure based on cation-exchange with Dowex AG 5 0W-X4 and Sc-47 elution with HCl/HF. This method gave 90-97% overall S c-47 recovery, with a Ti separation factor greater than 2.4 x 10(-5), and specific activities greater than or equal to 0.9 GBq mu g(-1). Use of the Sc-47 product, for labeling monoclonal antibodies, resulted in consistent labeling yields of greater than or equal to 90%. (C) 1998 Elsevier Science Ltd. All rights reserved.