EXAMINATION OF THE PREPARATION AND STABILITY OF (TCN)-TC-99M(NOET)(2)FROM THE [TC-EQUIVALENT-TO-N] INTERMEDIATE

The preparation and stability of the [Tc=N] intermediate and (TCN)-T-9 9m(NOEt)(2) (NOEt: N-ethoxy, N-ethyl dithiocarbamate) which is a poten tial myocardial imaging agent containing [Tc=N](2+) core, is reported. In the presence of a reducer and a donor of N, the [Tc=N] intermediat e could be conveniently synthesized at 100 degrees C, allowing the for mation of (TcN)-Tc-99m(NOEt)(2) by addition of NaNOEt at room temperat ure. The change of the composition of the intermediate was investigate d at different pH values, and the radiochemical purity (RCP) of the co mplex was evaluated by HPLC. The partition coefficient and stability i n vitro of (TcN)-Tc-99m(NOEt)(2) were determined, the complex had a RC P of over 90% and was stable for 6 h. (C) 1998 Elsevier Science Ltd. A ll rights reserved.