K. Kedziorakornatowska et M. Luciak, EFFECT OF ANGIOTENSIN CONVERTASE INHIBITORS ON LIPID-PEROXIDATION ANDPEROXYL RADICAL-TRAPPING CAPACITY IN RATS WITH EXPERIMENTAL DIABETES, Biochemistry and molecular biology international, 45(5), 1998, pp. 905-910
Effect of two angiotensin convertase inhibitors, enalapril and captopr
il, on blood plasma and erythrocyte lipid peroxidation and plasma pero
xyl radical-trapping capacity was studied in rats with streptozotocin-
induced diabetes. A progressive increase in blood erythrocyte malondia
ldehyde (MDA) level was observed in diabetic rats after 6 and 12 weeks
. Blood plasma MDA level increased while plasma peroxyl radical-trappi
ng capacity was decreased after 12 weeks. Captopril (2 mg/kg body weig
ht) augmented the diabetes-induced changes in MDA content after 6 week
s and prevented them after 12 weeks increasing also the peroxyl radica
l-trapping capacity. Enalapril (1 mg/kg body weight) counteracted the
diabetes-induced changes in MDA content after both 6 and 12 weeks but
did not affect the plasma peroxyl radical-trapping capacity. These res
ults suggest a possibility of a therapeutic use of angiotensin convert
ase inhibitors to attenuate the effects of oxidative stress in diabete
s.