MILD AND EFFICIENT CONVERSION OF NITRILES TO AMIDES WITH BASIC UREA-HYDROGEN PEROXIDE ADDUCT

Authors
BALICKI R KACZMAREK L
Citation
R. Balicki et L. Kaczmarek, MILD AND EFFICIENT CONVERSION OF NITRILES TO AMIDES WITH BASIC UREA-HYDROGEN PEROXIDE ADDUCT, Synthetic communications, 23(22), 1993, pp. 3149-3155
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
22
Year of publication
1993
Pages
3149 - 3155
Database
ISI
SICI code
0039-7911(1993)23:22<3149:MAECON>2.0.ZU;2-6
Abstract
The urea-hydrogen peroxide adduct, an inexpensive, stable and easily h andled reagent has shown utility for mild and efficient transformation of nitriles into the corresponding aliphatic or aromatic amides. Reac tion proceeds in aqueous acetone, within 0.5-2.5h, in the presence of catalytic amount of K2CO3, at room temperature.