VORICONAZOLE AGAINST FLUCONAZOLE-SUSCEPTIBLE AND RESISTANT CANDIDA ISOLATES - IN-VITRO EFFICACY COMPARED WITH THAT OF ITRACONAZOLE AND KETOCONAZOLE

We compared the in-vitro activity of fluconazole, itraconazole, ketoco nazole and voriconazole against 67 blood isolates of Candida spp. exhi biting a wide range of fluconazole MICs (0.125 to >64 mg/L). Voriconaz ole was the most potent in vitro, followed by itraconazole, ketoconazo le and fluconazole. Itraconazole and voriconazole had in-vitro activit y against fluconazole-susceptible and -resistant candida isolates. Hig her itraconazole and voriconazole MICs were observed in isolates exhib iting higher fluconazole MICs, suggesting cross-resistance. Itraconazo le and voriconazole MICs of greater than or equal to 16 mg/L were obse rved only in Candida albicans and Candida tropicalis. Candida krusei a nd Candida glabrata exhibited itraconazole MICs of 0.5-1 mg/L and vori conazole MICs of 0.25-0.5 mg/L.