A SIMPLE METHOD FOR THE DETERMINATION OF ARTICAINE AND ITS METABOLITEARTICAINIC ACID IN DENTISTRY - APPLICATION TO A COMPARISON OF ARTICAINE AND LIDOCAINE CONCENTRATIONS IN ALVEOLUS BLOOD

Authors
OERTEL R RICHTER K WEILE K GRAMATTE T BERNDT A FELLER K
Citation
R. Oertel et al., A SIMPLE METHOD FOR THE DETERMINATION OF ARTICAINE AND ITS METABOLITEARTICAINIC ACID IN DENTISTRY - APPLICATION TO A COMPARISON OF ARTICAINE AND LIDOCAINE CONCENTRATIONS IN ALVEOLUS BLOOD, Methods and findings in experimental and clinical pharmacology, 15(8), 1993, pp. 541-547
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
15
Issue
8
Year of publication
1993
Pages
541 - 547
Database
ISI
SICI code
0379-0355(1993)15:8<541:ASMFTD>2.0.ZU;2-N
Abstract
This study was undertaken to develop a time- and cost-effective method for the detection of articaine and articainic acid in alveolus blood by high-performance liquid chromatography with a simple method of samp le pretreatment. To overcome the problem of very rapid hydrolysis a me thod for controlling hydrolysis in vitro after blood sampling was deve loped. Blood samples were withdrawn from the alveolus of the upper mol ars 2-14 min after submucuos injection of articaine (2.0 ml 4%) or ide ntical injection of lidocaine (2.0 ml 2%). The higher blood levels fou nd for articaine correspond to the higher concentration of the drug in the injection solution. A relationship between the serum concentratio n of articaine and lidocaine, respectively, and the time between (sic) blood sampling could be established.