ACTIVITY OF MOXIDECTIN 1-PERCENT INJECTABLE SOLUTION AGAINST FIRST INSTAR HYPODERMA SPP. IN CATTLE AND EFFECTS ON ANTIBODY KINETICS

The activity of the moxidectin as an 1% w/v injectable solution on fir st instar Hypoderma spp, has been evaluated in sixteen naturally infes ted young cattle, The animals were selected on the basis of their sero logical status and allocated to two groups of eight animals, At the en d of November, one group was treated with moxidectin at a dose rate of 0.2 mg/kg via the subcutaneous route and the non treated control calv es injected with the vehicle. The serological status was assessed 1, 2 , 4, 8 and 12 weeks post treatment and the presence of Hypoderma lumps determined every two weeks from February to June. A 100% efficacy of the injectable formulation was demonstrated. A progressive fall of the antibody levels was observed in the treated calves for one month foll owing treatment, suggesting a progressive action of the test compound and a limited risk of hypersensitivity. (C) 1998 Elsevier Science B.V. All rights reserved.