A model explaining children's knowledge about medicines and the percei
ved benefit of medicines was constructed and estimated. The children's
health belief model, cognitive development and social cognitive devel
opment theories, combined with previous multimethod study results form
the basis of the path analytic model analyzed. Children, aged 7 and 1
0 years, and their primary caregivers were interviewed during 1992 and
1993. Recruiting was done at summer camps in Chapel Hill, North Carol
ina and environs, resulting in a convenience sample of 101 children, a
ll white and middle class. Ordinary least squares regression was carri
ed out in steps for the two model equations. Knowledge of medicines wa
s most adequately explained, having age, educational environment and t
he degree of internal locus of control as significant positive predict
ors. The only significant predictor of the perceived benefit of medici
nes was the negative effect of the internal locus of control, supporti
ng results from former studies. Children's retention of drug advertisi
ng had no significant effects in the model. The results from this mode
rately sized study suggest promising directions for further developmen
t of explanations of why children believe in the benefit of medicines.