UNRAVELING THE MYSTERY OF GOLDBLATT HYPERTENSION

In hypertension caused by unilateral renal artery stenosis, the nonste notic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated infrarenal angi otensin II (ANG II) content. Rats chronically infused with ANG II exhi bit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II f ormation, which provide a hypertensinogenic stimulus.