Surgical procedures in patients with peritonitis and sepsis have had t
he best results caused by focus sanitation with a reduced risk of mort
ality. Adjuvant therapies have a lot of possibilities and different wa
ys. The used cytokine-antibodies or inhibitors are still lacking of ge
neral acceptable results, successful treatments have been published on
ly in subgroups. An important drug is taurolidine, an antibacterial ch
emotherapeutic drug, in intraperitoneal or intravenous application rou
te. The well known immunomodulation from this drug improves the patien
t outcome. The overwhelming majority of data suggests a positive thera
peutic effect.