A HYPERESTROGENIC STATE AS AN ETIOLOGIC FACTOR IN FEMALE FERTILE PATIENTS WITH DYSPLASTIC CERVICAL TISSUE

We have assayed the levels of oestrogen and progesterone receptors in 41 precancerous cervix lesions obtained from premenopausal patients an d compared them with levels in 10 tissues from premenopausal normal wo men. The mean age was 31 years (aged 20-42 years). All of the women ha d ovulatory biphasic-cycles according to basal body temperature and a plasma prolactin level in the normal range. Their corpus luteum functi on was evaluated by way of plasma progesterone and oestradiol determin ations at days 7 and 9 of the hyperthermic phase. Satisfactory specime ns suitable for colposcopy and histological examination were obtained for hormonal receptors determination. When the patients were grouped a ccording to type of cervix lesion, it appeared that plasma oestradiol was constantly elevated in all groups as compared with the level in no rmal women. Plasma progesterone was normal in the groups of patients w ith either cervical neoplasia. Hormonal factors are hypothesized to in fluence cervical intraepithelial neoplasia through several mechanisms. Med Sci Res 26:457-459 (C) 1998 Lippincott-Raven Publishers.