IS OUABAIN PRODUCED BY THE ADRENAL-GLAND

Citation
Rh. Foster et al., IS OUABAIN PRODUCED BY THE ADRENAL-GLAND, General pharmacology, 31(4), 1998, pp. 499-501
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
03063623
Volume
31
Issue
4
Year of publication
1998
Pages
499 - 501
Database
ISI
SICI code
0306-3623(1998)31:4<499:IOPBTA>2.0.ZU;2-P
Abstract
1. Ouabain or a related stereoisomer, termed endogenous ouabain, has b een identified in adrenal cortex tissue and culture medium from adreno cortical cells. 2. Angiotensin II and adrenocorticotropin, the main ac tivators of aldosterone secretion from adrenal glomerulosa cells appea r to increase the production of this compound. 3. The purpose of this review is to briefly discuss recent available experimental evidence su ggesting that endogenous ouabain is secreted by the zona glomerulosa o f the adrenal gland. (C) 1998 Elsevier Science Inc.