IS OUABAIN PRODUCED BY THE ADRENAL-GLAND

1. Ouabain or a related stereoisomer, termed endogenous ouabain, has b een identified in adrenal cortex tissue and culture medium from adreno cortical cells. 2. Angiotensin II and adrenocorticotropin, the main ac tivators of aldosterone secretion from adrenal glomerulosa cells appea r to increase the production of this compound. 3. The purpose of this review is to briefly discuss recent available experimental evidence su ggesting that endogenous ouabain is secreted by the zona glomerulosa o f the adrenal gland. (C) 1998 Elsevier Science Inc.