ADENOSINE AND THE NERVOUS-SYSTEM - PHARMACOLOGICAL DATA AND THERAPEUTIC PERSPECTIVES

1. Adenosine acts on a family of G-protein-coupled receptors called pu rinoreceptors. 2, Four subtypes have been cloned and pharmacologically characterized. 3. The principal pharmacological data and structure-fu nction relations for agonist interactions with P1 receptors are presen ted. 4. We conclude that the potent role of adenosine in the nervous s ystem may be interesting for the development of drugs targeted at puri nes and their receptors. (C) 1998 Elsevier Science Inc.