SYNTHESIS OF HYALURONIC-ACID-RELATED OLIGOSACCHARIDES AND ANALOGS, ASTHEIR 4-METHOXYPHENYL GLYCOSIDES, HAVING N-ACETYL-BETA-D-GLUCOSAMINE AT THE REDUCING END

To contribute to the possibilities to study the ability of oligosaccha ride fragments of hyaluronic acid to induce angiogenesis, several hyal uronic-acid-related oligosaccharides and their 6-0-sulfated analogues were synthesised as their 4-methoxyphenyl glycosides having 2-acetamid o-2-deoxy-D-glucopyranose at the reducing end. In all syntheses descri bed, the D-glucopyranosyluronic acid residue was obtained by oxidation at C-6 of a corresponding D-glucopyranosyl residue after construction of the oligosaccharide backbone, using pyridinium dichromate and acet ic anhydride. (C) 1998 Elsevier Science Ltd. All rights reserved.