TELOMERASE ACTIVATION IN HUMAN CANCERS

Objective To review the background of telomerase activation and the me thodology involved in its determination, and the clinico-pathological significance of telomerase activation in human cancers. Data sources A n English-language literature search using MEDLINE (1966-1997) and bib liographic reviews of textbooks and review articles. Results Progressi ve shortening of telomeres was associated with continuous cell divisio n in normal somatic cells. Telomerase was activated in most cancer cel ls and immortal germ cells to maintain their telomeric lengths. The oc currence and clinical pathological significance of telomerase activati on was evaluated in various types of human cancer. Conclusions Telomer ase activation is a common event in human cancers and may be as a usef ul marker for malignant cells. Telomerase may also be a therapeutic ta rget for cancer treatment.