A MULTIPLE-PATH MODEL OF FIBER DEPOSITION IN THE RAT LUNG

An asymmetric multiple-path model of particle deposition in the lung a irways developed previously (S. Anjilvel and B. Asgharian, 1995, Funda m. Appl. Toxicol. 28, 41-50), was extended to calculate deposition of fibers in the rat lung by replacing the deposition efficiency expressi ons for particles with those of fibers, The effects of various paramet ers such as breathing parameters or fiber dimensions on deposition wer e: studied. Fiber deposition fraction for one single breath was calcul ated per acini, lobe, and region of interest in the lung, The results were compared with one other model prediction and with data available in the literature. Good agreement between the model predictions and ot her studies was found, (C) 1998 Society of Toxicology.