SO-CALLED NASAL GLIOMA - CASE-REPORT WITH IMMUNOHISTOCHEMICAL STUDY

The so-called nasal gliomas (nasal cerebral heterotopias) are rare, co ngenital, benign masses of neurogenic origin with intra or extranasal location, or both. An intranasal case is reported in a 7-month-old inf ant who successfully underwent surgery with the intranasal approach. T he tumor had no intracranial extension and the child is free of diseas e after a three-year follow-up, Immunohistochemical study confirmed th e glial (GFAP+) and neuronal (NSE+) nature of the cells composing the mass. In addition to the clinical behavior, the benign nature of the t umor is also indicated by the negativity of Ki67 (MIB-1) and p53 proli feration markers as well as by CD44 negativity. As far as we know, thi s is the first reported case of nasal glioma subjected to immunohistoc hemical investigation of proliferation activity.