SOLUBILITY PREDICTION OF N-FATTY ALCOHOLS AND STEROLS IN COMPLEXING AND NON-COMPLEXING SOLVENTS ACCORDING TO THE MOBILE ORDER THEORY

The volume fraction solubilities of a number of solid n-fatty alcohols and sterols are predicted in neat organic nonpolar, polar, and hydrog en-bonded solvents including water. In the frame of the mobile order t hermodynamics, the predictions are based on the knowledge (a) of the m elting properties of the alcohols, which affect the fluidization proce ss, (b) of their molar size, which mainly rules the exchange entropy a nd the hydrophobic effect, and (c) of the group interaction stability constants, which are responsible for the balance between the competing self-association and strong intermolecular interactions of the alcoho ls in solution. Owing to its ability to deal properly with these vario us elementary processes, the proposed thermodynamic solubility model d erived from the mobile order theory in H-bonded liquids represents an advance towards reliable and comprehensive estimates of the solubilizi ng capacity of common solvents for nonideal complexing systems, i.e., the solid alcohols.