F. Aoudjit et al., PROTECTION FROM LYMPHOMA CELL METASTASIS IN ICAM-1 MUTANT MICE - A POSTHOMING EVENT, The Journal of immunology (1950), 161(5), 1998, pp. 2333-2338
It has been hypothesized that the intercellular adhesion receptors use
d by normal cells could also be operative in the spreading of circulat
ing malignant cells to target organs. In the present work, we show tha
t genetic ablation of the ICAM-1 gene confers resistance to T cell lym
phoma metastasis, Following i.v. inoculation of LFA-1-expressing malig
nant T lymphoma cells, we found that ICAM-1-deficient mice were almost
completely resistant to the development of lymphoid malignancy compar
ed with wild-type control mice that developed lymphoid tumors in the k
idneys, spleen, and liver, Histologic examinations confirmed that ICAM
-1-deficient mice, in contrast to wild-type mice, had no evidence of l
ymphoid infiltration in these organs. The effect of ICAM-1 on T cell l
ymphoma metastasis was observed in two distinct strains of ICAM-1-defi
cient animals. Nonetheless, lymphoma cells migrated with the same effi
ciency to target organs in both normal and ICAM-1-deficient mice, indi
cating not only that ICAM-1 expression by the host is essential in lym
phoma metastasis, but also that this is so at stages subsequent to hom
ing and extravasation into target organs. These results point to posth
oming events as a focus of future investigation on the control of meta
stasis mediated by ICAM-1.