ANTIMYCOBACTERIAL EVALUATION OF GERMACRANOLIDES

Authors
FISCHER NH LU TS CANTRELL CL CASTANEDAACOSTA J QUIJANO L FRANZBLAU SG
Citation
Nh. Fischer et al., ANTIMYCOBACTERIAL EVALUATION OF GERMACRANOLIDES, Phytochemistry, 49(2), 1998, pp. 559-564
Citations number
30
Categorie Soggetti
Biology,"Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
49
Issue
2
Year of publication
1998
Pages
559 - 564
Database
ISI
SICI code
0031-9422(1998)49:2<559:AEOG>2.0.ZU;2-5
Abstract
The minimum inhibitory concentrations (MIC) against Mycobacterium tube rculosis and M. avium of parthenolide, costunolide, 1 (10)-epoxycostun olide and other germacranolide-type sesquiterpene lactones and derivat ives were determined by use of a radiorespirometric bioassay. Structur e-activity relationship studies with natural and semisynthetic sesquit erpene lactones suggested that the alpha-methylene-gamma-lactone moiet y is an essential, but not sufficient, structural requirement for sign ificant in vitro activity against M. tuberculosis and M. avium. (C) 19 98 Elsevier Science Ltd. All rights reserved.