EFFICACY OF SURGICAL AND OR PODOPHYLLOTOXIN TREATMENT AGAINST FLAT ACETOWHITE PENILE HUMAN-PAPILLOMAVIRUS ASSOCIATED LESIONS/

In order to investigate the efficacy of treatment modalities favoured by us against flat acetowhite penile human papillomavirus (HPV)-induce d lesions, we studied retrospectively standardized medical records of 81 men who had been treated for this condition. The patients were trea ted surgically with diathermy (n=32) or with a combination of both che mical (topical application of podophyllotoxin) and surgical treatment (n=49). The mean number of clinic visits was 9.1 (range 1-19), during a follow-up time of mean 30.9 (range 1-104) months for 78 of the men, 3 of them only visited the clinic once. The mean time for cure was 19. 9 (range 0-103) months. Only 12 (15%) patients were healed after one s ingle treatment session, while as many as 50 (62%) required >4 session s. The mean number of surgical treatment sessions required for cure di ffered significantly (P=0.0006) between the previously treated patient s who needed a mean of 5.6 treatment sessions, compared to the previou sly untreated men who required surgery a mean of 3.4 times for cure.