PROSTAGLANDIN-INDEPENDENT STIMULATION OF INTERLEUKIN-6 PRODUCTION BY FIBRINOGEN DEGRADATION PRODUCT-D IN PERFUSED MURINE LIVER

Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liv er, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse live rs. Indomethacin inhibited the effect of LPS significantly but was ine ffective in the case of FDP-D. Accordingly, production of prostaglandi ns D-2 and E-2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time i nterleukin-l (IL-1) production in perfused liver rose markedly upon th e addition of FDP-D. It is suggested that prostaglandins are not invol ved in the effects of FDP-D on the liver. The stimulatory effect of FD P-P on IL-6 production might be the consequence of elevated IL-1 level s.