CHARACTERIZATION OF VIRAL DOUBLE-STRANDED RNA-BINDING PROTEINS

Several viruses have been shown to code for proteins that specifically bind to double-stranded RNA or RNA with large amounts of secondary st ructure. These proteins have been implicated in providing interferon r esistance to viruses and in inhibiting induction of apoptosis by virus es, and have been suggested to be involved in regulation of viral and cellular protein synthesis in infected cells. This article describes m ethods for detecting and analyzing viral double-stranded RNA binding p roteins. (C) 1998 Academic Press.