Y. Liao et al., PREPARATION OF (S)-(-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN AND (R)-(-)-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN()), Enantiomer, 3(1), 1998, pp. 19-22
8-Trifluoromethanesulfonyloxymianserin (3) was synthesized. Its enanti
omers were separated by means of HPLC using a chiral stationary phase
in the semipreparative mode (100 mg scale) in greater than or equal to
99% optical purity. Reduction of the enantiomers of 3 under catalytic
hydrogenation conditions gave the mianserin enantiomers in high purit
y. The absolute configuration of the enantiomers of 3 were assigned by
comparing their respective optical rotations with those of the mianse
rin enantiomers.