PREPARATION OF (S)-(-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN AND (R)-(-)-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN())

Authors
LIAO Y SELDITZ U DEZEEUW RA WIKSTROM H
Citation
Y. Liao et al., PREPARATION OF (S)-(-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN AND (R)-(-)-8-TRIFLUOROMETHANESULFONYLOXYMIANSERIN()), Enantiomer, 3(1), 1998, pp. 19-22
Citations number
20
Categorie Soggetti
Chemistry,"Chemistry Inorganic & Nuclear",Biology
Journal title
Enantiomer → ACNP
ISSN journal
10242430
Volume
3
Issue
1
Year of publication
1998
Pages
19 - 22
Database
ISI
SICI code
1024-2430(1998)3:1<19:PO(A(>2.0.ZU;2-1
Abstract
8-Trifluoromethanesulfonyloxymianserin (3) was synthesized. Its enanti omers were separated by means of HPLC using a chiral stationary phase in the semipreparative mode (100 mg scale) in greater than or equal to 99% optical purity. Reduction of the enantiomers of 3 under catalytic hydrogenation conditions gave the mianserin enantiomers in high purit y. The absolute configuration of the enantiomers of 3 were assigned by comparing their respective optical rotations with those of the mianse rin enantiomers.