SANNAMYCIN-TYPE AMINOGLYCOSIDE ANTIBIOTICS - EFFICIENT SYNTHESES - BIOLOGICAL-ACTIVITY

Authors
ERBECK S LIANG XF HUNKLER D KRIEGER R PRINZBACH H
Citation
S. Erbeck et al., SANNAMYCIN-TYPE AMINOGLYCOSIDE ANTIBIOTICS - EFFICIENT SYNTHESES - BIOLOGICAL-ACTIVITY, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (9), 1998, pp. 1935-1948
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY → ACNP
ISSN journal
1434193X
Issue
9
Year of publication
1998
Pages
1935 - 1948
Database
ISI
SICI code
1434-193X(1998):9<1935:SAA-ES>2.0.ZU;2-K
Abstract
Shorter and more efficient routes to 6'-des(N-methyl)sannamycin A (1) and its 2'-epi analog 2 have been elaborated with the proven sannamine -type acceptor 10 and the glycosyl donors 5-8 featuring novel protecti ng patterns. With glycal 9 as glycosyl donor (and 10) an expedient acc ess to 2'-desamino- (3) and 2'-desamino-2'-epi-hydroxysanna-mycin A (4 ) has been opened. For 4 a modest antibacterial activity was found, wh ile 3 was inactive.