PERSPECTIVES OF GLUTAMINE AND ITS DERIVATIVES AS FEED ADDITIVES FOR FARM-ANIMALS

Glutamine and its derivatives e.g., alpha-ketoglutaric acid (AKG) or o rnithine- alpha-ketoglutarate (OKG) are molecules with a central role (via the Krebs cycle) in systemic, intestinal and gut bacterial metabo lism Studies have shown that AKG is a precursor not only of glutamine and arginine, but also of some other keto acids e.g., alpha-ketoisocap roate which in turn is a precursor of hydroxy-methyl-butyrate, which i tself is regarded as a protein catabolic protector. Recently it has be en postulated that AKG is not only an important energy donor, but that it also functions as an ammonium ion scavenger via transformation to glutamate, ornithine and putrescine and finally to GABA or succinate. Several beneficial effects of AKG have been reported in human medicine e.g., improved patients' recovery following gastrointestinal surgery. On the other hand, is was reported that 100 per cent glutamate metabo lism in the first pass in infant pigs' small intestine. In the current presentation we discuss the potential benefits of using glutamine der ivatives in human clinical nutrition as well as their role as feed add itives in the production of farm animals.