FACILE SYNTHESIS OF SOME NEW PYRAZOLO[3,4-B]PYRAZINES AND THEIR ANTIFUNGAL ACTIVITY

The synthesis of new pyrazolo[3,4-b]pyrazines and related heterocycles has been reported. The key intermediate 1,6-diphenyl-3-methyl-1 H-pyr azolo[ 3,4-b]pyrazine-5-carbonitrile 2 was obtained in one pot synthes is from the reaction of 5-amino-3-methyl-4-nitroso-1-phenyl-pyrazole 1 with benzoylacetonitrile. Modest antifungal activity was shown for so me of the prepared compounds. (C) 1998 Elsevier Science S.A. All right s reserved.