Pa. Kostamovaara et al., KETOROLAC, DICLOFENAC AND KETOPROFEN ARE EQUALLY EFFICACIOUS FOR PAINRELIEF AFTER TOTAL HIP-REPLACEMENT SURGERY, British Journal of Anaesthesia, 81(3), 1998, pp. 369-372
We have compared the efficacy of ketorolac 30 mg i.v. followed by infu
sion at a rate of 90 mg/15.5 h, with that of diclofenac 75 mg followed
by infusion of 75 mg/15.5 h or ketoprofen 100 mg followed by infusion
of 100 mg/15.5 h, on postoperative pain in 85 patients after hip repl
acement surgery under spinal anaesthesia in a prospective, double-blin
d, randomized study. Supplementary analgesia was administered during t
he 16-h postoperative period with bolus doses of fentanyl delivered by
a patient-controlled analgesia system. Mean total consumption of PCA-
administered fentanyl was 890 (SD 400) mu g in the ketorolac group, 92
0 (550) mu g in the diclofenac group and 850 (350) mu g in the ketopro
fen group (ns). Median VAS scores were low over the entire study in ea
ch group and there was no significant difference between groups. No se
rious adverse events were recorded.