CONSTRUCTION OF COMBINATORIAL CHEMICAL LIBRARIES USING A RAPID AND EFFICIENT SOLID-PHASE SYNTHESIS BASED ON A MULTICOMPONENT CONDENSATION REACTION

Authors
KIM SW BAUER SM ARMSTRONG RW
Citation
Sw. Kim et al., CONSTRUCTION OF COMBINATORIAL CHEMICAL LIBRARIES USING A RAPID AND EFFICIENT SOLID-PHASE SYNTHESIS BASED ON A MULTICOMPONENT CONDENSATION REACTION, Tetrahedron letters, 39(39), 1998, pp. 6993-6996
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
39
Year of publication
1998
Pages
6993 - 6996
Database
ISI
SICI code
0040-4039(1998)39:39<6993:COCCLU>2.0.ZU;2-R
Abstract
A 96 member library of acylated dipeptides based on a known anticonvul sant was synthesized utilizing an Ugi four component condensation foll owed by derivitization through nucleophilic displacement of a Weinreb type amide. The library afforded compounds in reasonable yield and hig h purity after cleavage from solid support. (C) 1998 Elsevier Science Ltd. All rights reserved.