BENZOTRIAZOLE MEDIATED SYNTHESES OF ALPHA-FLUORO-BETA-AMINO ESTERS

Authors
KATRITZKY AR NICHOLS DA QI M
Citation
Ar. Katritzky et al., BENZOTRIAZOLE MEDIATED SYNTHESES OF ALPHA-FLUORO-BETA-AMINO ESTERS, Tetrahedron letters, 39(39), 1998, pp. 7063-7066
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
39
Year of publication
1998
Pages
7063 - 7066
Database
ISI
SICI code
0040-4039(1998)39:39<7063:BMSOAE>2.0.ZU;2-J
Abstract
Mono- and difluoro-beta-amino esters were synthesized via Reformatsky reaction of fluorinated ethyl bromoacetates with N-(alpha-aminoalkyl)b enzotriazoles. Secondary and tertiary amines are easily formed, but pr imary amines can only be made in the difluorinated case. This approach has led to the first synthesis of di- and tetrafluorinated bis(beta-a mino esters). (C) 1998 Elsevier Science Ltd. All rights reserved.