REGIOSELECTIVE SYNTHESIS OF 2-ARYLPROPIONIC ESTERS BY PALLADIUM-CATALYZED HYDROESTERIFICATION OF STYRENE DERIVATIVES IN MOLTEN-SALT MEDIA

Authors
ZIM D DESOUZA RF DUPONT J MONTEIRO AL
Citation
D. Zim et al., REGIOSELECTIVE SYNTHESIS OF 2-ARYLPROPIONIC ESTERS BY PALLADIUM-CATALYZED HYDROESTERIFICATION OF STYRENE DERIVATIVES IN MOLTEN-SALT MEDIA, Tetrahedron letters, 39(39), 1998, pp. 7071-7074
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
39
Year of publication
1998
Pages
7071 - 7074
Database
ISI
SICI code
0040-4039(1998)39:39<7071:RSO2EB>2.0.ZU;2-M
Abstract
The palladium-catalyzed hydroesterification of styrene derivatives is performed in a two-phase system composed of 1-n-butyl-3-methylimidazol iumtetrafluoroborate salt (ionic phase) and isopropanol/cyclohexane (o rganic phase). Very high regioselectivities in 2-arylpropionic esters (greater than or equal to 99.5%) are obtained using a catalytic system composed of PdCl2(PhCN)(2), (+)-neomenthyldiphenylphosphine (NMDPP) a nd p-toluenesulfonic acid under mild reaction conditions (10 atm and 7 0 degrees C). (C) 1998 Elsevier Science Ltd. All rights reserved.