SUPPRESSION EFFECT OF THE PD C-CATALYZED HYDROGENOLYSIS OF A PHENOLICBENZYL PROTECTIVE GROUP BY THE ADDITION OF NITROGEN-CONTAINING BASES/

Authors
SAJIKI H KUNO H HIROTA K
Citation
H. Sajiki et al., SUPPRESSION EFFECT OF THE PD C-CATALYZED HYDROGENOLYSIS OF A PHENOLICBENZYL PROTECTIVE GROUP BY THE ADDITION OF NITROGEN-CONTAINING BASES/, Tetrahedron letters, 39(39), 1998, pp. 7127-7130
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
39
Year of publication
1998
Pages
7127 - 7130
Database
ISI
SICI code
0040-4039(1998)39:39<7127:SEOTPC>2.0.ZU;2-D
Abstract
A mild and chemoselective hydrogenation method using 5% Pd/C for olefi n, N-Cbz, benzyl ester and nitro functionalities distinguishing from t he benzyl protective group for the phenolic hydroxyl group has been de veloped by the employment of 2,2'-dipyridyl as an additive. The suppre ssive effect on the benzyl ether hydrogenolysis was strongly influence d by the sorts of nitrogen-containing bases employed as an additive. ( C) 1998 Elsevier Science Ltd. All rights reserved.