P. Rossi et al., A NEW LIGAND ALPHA-AMINO-ACID - )-2-AMINO-3-[1-(1,4,7-TRIAZACYCLONONANE)]PROPANOIC ACID, Tetrahedron letters, 39(39), 1998, pp. 7159-7162
The title amino acid was obtained by regiospecific ring-opening reacti
on of Boc-diprotected 1,4,7-triazacyclononane with (S)-2-beazyloxycarb
onylamino-beta-lactone 80% isolated yield) followed by deprotection. I
t strongly binds transition metal ions like Zn and Cu-II and can be in
corporated in peptide sequences without affecting the metal ion affini
ty of the triazamacrocycle. (C) 1998 Elsevier Science Ltd. All rights
reserved.