SYNTHESIS OF A CONFORMATIONALLY RESTRICTED ANALOG OF PACLITAXEL

Authors
BARBONI L LAMBERTUCCI C BALLINI R APPENDINO G BOMBARDELLI E
Citation
L. Barboni et al., SYNTHESIS OF A CONFORMATIONALLY RESTRICTED ANALOG OF PACLITAXEL, Tetrahedron letters, 39(39), 1998, pp. 7177-7180
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
39
Year of publication
1998
Pages
7177 - 7180
Database
ISI
SICI code
0040-4039(1998)39:39<7177:SOACRA>2.0.ZU;2-0
Abstract
A conformationally constrained analogue of the paclitaxel side-chain w as synthesised in an enantioselective way from ethyl 1H-indene-2-carbo xylate. Coupling with 7-triethylsilylbaccatin III and deprotection aff orded 2',2 ''-methylenepaclitaxel, a novel analogue of the natural pro duct retaining anticancer activity. (C) 1998 Elsevier Science Ltd. All rights reserved.