THE LONG-TERM PROGNOSIS OF BENIGN NEPHROSCLEROSIS ACCOMPANIED BY FOCAL GLOMERULOSCLEROSIS AND RENAL CORTICAL INTERSTITIAL FIBROSIS, DESIGNATED SO-CALLED DECOMPENSATED BENIGN NEPHROSCLEROSIS BY FAHR, BOHLE AND RATSCHECK

The longterm prognosis of decompensated benign nephrosclerosis (DBN) w as investigated by a retrospective analysis of the fate of 170 patient s with this disease, which yielded the following results: 1) DBN carri es a particularly poor prognosis. The renal survival rate (RSR) was 35 .9% at 5 years and 23.6% at 10 years. The prognosis is therefore worse than that of any other primary glomerulopathy, with the exception of rapidly progressive glomerulonephritis. 2) DBN mainly affects males (s ex ratio 5:1) and differs in this respect, among others, from focal sc lerosing glomerulonephritis, in which the male:female ratio is 1.2:1. 3) The prognosis for females is no better than for males. 4) The sever ity of proteinuria at the time of biopsy has no influence on the progn osis. 5) The prognosis is particularly poor in cases in which the seru m creatinine concentration is already elevated to more than 2.0 mg% at the time of biopsy. We conclude from these findings that not only the blood pressure, but also the serum creatinine concentration, should b e assessed at regular intervals in all hypertensive individuals, so th at DBN can be treated at an early stage, when it is still amenable to treatment.