CLINICAL EFFICACY AND SAFETY OF BECLOMETHASONE DIPROPIONATE INHALATION CAPSULES INHALED BY CYCLOHALER COMPARED WITH BECOTIDE ROTACAPS INHALED BY ROTAHALER

The study was undertaken to compare the efficacy and safety of beclome thasone dipropionate inhalation powder inhaled by Rotahaler (Becotide Rotacaps, Glare Wellcome) and by Cyclohaler (Beclomethasone Cyclocaps, Pharmachemie). Both the Cyclohaler and the Rotahaler are single-dose dry powder inhalation devices for inhalation capsules. 182 asthma pati ents stabilized on inhaled beclomethasone dipropionate 800 micrograms daily, were randomly assigned to treatment with 800 micrograms beclome thasone dipropionate inhaled by Rotahaler (91 patients) or Cyclohaler (91 patients) in a double-blind manner, using the double-dummy method. It was shown that the asthma remained stable during the 16-week study period with both preparations. There were no statistically significan t differences in the pulmonary parameters (morning PEF, evening PEF, F EV1). The test/reference ratio of the morning PEF (99.5%, CI 93.0% - 1 06.5%) was well within the equivalence interval, which had been set a priori from 85% to 117.6%. There were no marked differences between th e Cyclocaps and Rotacaps group in symptom scores and adverse events. A total of 12 patients had an asthma exacerbation: 8 exacerbations occu rred in the Rotahaler group and 4 in the Cyclohaler group. The differe nce was not statistically significant. The use of rescue medication wa s somewhat higher in the Rotahaler group, but the difference did not r each statistical significance. Significantly more patients (17 patient s) withdrew from the study in the Rotahaler group than in the Cyclohal er group (5 patients). In conclusion, there was no difference in asthm a control of patients treated with Beclomethasone Cyclocaps inhaled by Cyclohaler and Becotide Rotacaps inhaled by Rotahaler. Both preparati ons are therapeutically equivalent.