RELATION OF ARTERIAL GEOMETRY TO LUMINAL NARROWING AND HISTOLOGIC MARKERS FOR PLAQUE VULNERABILITY - THE REMODELING PARADOX

Citation
G. Pasterkamp et al., RELATION OF ARTERIAL GEOMETRY TO LUMINAL NARROWING AND HISTOLOGIC MARKERS FOR PLAQUE VULNERABILITY - THE REMODELING PARADOX, Journal of the American College of Cardiology, 32(3), 1998, pp. 655-662
Citations number
33
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
07351097
Volume
32
Issue
3
Year of publication
1998
Pages
655 - 662
Database
ISI
SICI code
0735-1097(1998)32:3<655:ROAGTL>2.0.ZU;2-9
Abstract
Objective. To relate local arterial geometry with markers that are tho ught to be related to plaque rupture. Background. Plaque rupture often occurs at sites with minor luminal stenosis and has retrospectively b een characterized by colocalization of inflammatory cells. Recent stud ies have demonstrated that luminal narrowing is related with the mode of atherosclerotic arterial remodeling. Methods. We obtained 1,521 cro ss section slices at regular intervals from 50 atherosclerotic femoral arteries. Per artery, the slices with the largest and smallest lumen area, vessel area and plaque area were selected for staining on the pr esence of macrophages (CD68), T-lymphocytes (CD45RO), smooth muscle ce lls (alpha-actin) and collagen. Results. Inflammation of the cap or sh oulder of the plaque was observed in 33% of all cross sections. Signif icantly more CD68 and CD45RO positive cells, more atheroma, less colla gen and less alpha-actin positive staining was observed in cross secti ons with the largest plaque area and largest vessel area vs. cross sec tions with the smallest plaque area and smallest vessel area, respecti vely. No difference in the number of inflammatory cells was observed b etween cross sections,vith the largest and smallest lumen area. Conclu sion. Intraindividually, pathohistologic markers previously reported t o be related to plaque vulnerability were associated,vith a larger pla que area and vessel area. In addition, inflammation of the cap and sho ulder of the plaque was a common finding in the atherosclerotic femora l artery. (J Am Coil Cardiol 1998;32:655-62) (C) 1998 by the American College of Cardiology.