TOXICITY OF COMBINATION OF FLUORIDE AND MONOCROTOPHOS 36-PERCENT SL TO WISTAR RAT

Groups of Wistar rat were given 1/2 and 1/4 LD50 of fluoride (F), 1/2 and 1/4 LD50 of monocrotophos 36% SL(MCP), and a combination of F+MCP (1/4 LD50 F+1/4 LD50 MCP), daily by oral intubation for 14 consecutive days. Cumulative body weight gain decreased in group of rats given 1/ 2 LD50 of F, and combination of F+MCP. None of the haematological para meters was affected in any of the groups. Protein decreased in all the treated groups, except in rats given 1/4 LD50 of F.GPx was not affect ed in any group. A significant decrease in the weight of the spleen wa s observed in rats given 1/4 ED50 of F and MCP. Since increase in GSH has been stated as a result of the defensive mechanism against toxicit y, it may be stated that Wistar rats were thus able to protect from th e toxic effects of the doses of fluoride, monocrotophos 36% SL or the combination of fluoride+monocrotophos employed in the study.