FOCUSING OF THERAPEUTIC ULTRASOUND THROUGH A HUMAN SKULL - A NUMERICAL STUDY

A numerical model was developed which can use digitized layer interfac es to calculate ultrasound wave absorption, diffraction, reflection, a nd refraction. This model was used to evaluate the feasibility of ultr asound therapy and surgery through a human skull. A digitized human sk ull profile was obtained from magnetic resonance (MR) images and used to calculate the ultrasound field in the brain of a volunteer from a s pherically curved phased array. With no phase correction, the focus of the array was shifted and defocused. The phased array technique was u sed to correct focal shift, reduce side lobes, and enhance focal ampli tude. The optimum source element width was estimated for each frequenc y to obtain a near optimium focus, and an appropriate frequency range for transskull ultrasound therapy and surgery was determined. Acoustic pressure amplitude on the skull surfaces was examined, and it was sho wn that the skull heating problem could be overcome. Despite high atte nuation, complex interface shape, and nonuniform thickness of a human skull, a sharply focused transskull ultrasound field can be generated for noninvasive ultrasound therapy and surgery in the brain. (C) 1998 Acoustical Society of America. [S0001-4966(98)03709-6]