The article relates details of the history of research into the causal
association of cigarette smoking and lung cancer on the basis of mult
idisciplinary studies that have explored the epidemiology, biology, ch
emistry, and biochemistry of tobacco carcinogenesis and research in be
havioral sciences and health education that has sought to address one
of our nation's foremost public health problems. Recalling past and pr
esent challenges and achievements in all of these areas, the author th
en outlines his vision for addressing this health problem in the futur
e. This is laid out for various segments of the research community and
for society as a whole, i.e., Cancer Centers and hospitals, epidemiol
ogists, laboratory scientists, legislators, educators and behavioral s
cientists, and the media. It is proposed that for the current policy i
nitiatives in tobacco-related cancer control to succeed, there needs t
o be a focus on preventing the initiation of tobacco use among childre
n and adolescents. All segments of society can help to achieve this go
al. In the nation's research planning, there needs to be a proper bala
nce between basic and applied research, including research on and appl
ication of preventive principles, because cancer need not be an inevit
able consequence of aging but is largely preventable.