EVALUATION OF FOCAL CEREBRAL-ISCHEMIA IN RATS BY MAGNETIC-RESONANCE-IMAGING AND IMMUNOHISTOCHEMICAL ANALYSES

Authors
ISHII H ARAI T MORIKAWA S INUBUSHI T TOOYAMA I KIMURA H MORI K
Citation
H. Ishii et al., EVALUATION OF FOCAL CEREBRAL-ISCHEMIA IN RATS BY MAGNETIC-RESONANCE-IMAGING AND IMMUNOHISTOCHEMICAL ANALYSES, Journal of cerebral blood flow and metabolism, 18(9), 1998, pp. 931-934
Citations number
9
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism",Hematology
Journal title
Journal of cerebral blood flow and metabolism → ACNP
ISSN journal
0271678X
Volume
18
Issue
9
Year of publication
1998
Pages
931 - 934
Database
ISI
SICI code
0271-678X(1998)18:9<931:EOFCIR>2.0.ZU;2-1
Abstract
Correlation of focal ischemia-induced brain damage evidenced by magnet ic resonance imaging (MRI) and by staining with microtubule-associated protein 2 (MAP2) was studied in rats. Ischemia was produced by transi ent occlusion of the middle cerebral artery (MCAO). The damage was ass essed at 6 to 8 hours after MCAO and 1 week later. The area of damage assessed by MRI agreed with that by MAP2 staining at 6 to 8 hours afte r MCAO, which was smaller (P < 0.001) than that defined by MAP2 staini ng 1 week after MCAO. Glial staining indicated that glial infiltration affected the signal intensity of MRI in the area of damage.