ENTROPY MAPS CHARACTERIZE DRUG EFFECTS ON BRAIN DYNAMICS IN ALZHEIMERS-DISEASE

Non-linear quantifiers of brain electrical dynamics (entropy maps comp uted from the degradation of temporal forecasting of EEG signals) were studied in relation to drug treatment of Alzheimer's disease. A place bo condition was compared to three drug doses (50, 100 and 200 mg). A significant general effect of the drug was found when compared to plac ebo and specific contrasts between placebo and each of the three drug doses only reveal a significant entropy increase for the highest dose. These effects were localized bilaterally in fronto-temporal areas and support changes in the dynamics of the cerebral structures involved i n memory processes. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.