TRANSITIONAL-CELL CARCINOMA PRESENTING AS A SOLITARY BRAIN LESION - ACASE-REPORT AND REVIEW OF THE WORLD LITERATURE

Transitional cell carcinoma of the urinary tract will account for roug hly 50,000 new cases of cancer in the US this year. Metastatic involve ment to the brain is uncommon with this malignancy. When it does occur , it is usually in the setting of widespread metastatic disease. A rar e case of transitional cell carcinoma of the bladder presenting as a s olitary brain lesion is reported. In addition, we reviewed the world l iterature regarding transitional cell carcinoma metastatic to the cent ral nervous system. Our review suggests that metastatic transitional c ell carcinoma of the central nervous system has become increasingly co mmon as more effective chemotherapeutic regimens have been developed t o control the primary disease. The recent literature also suggests tha t, much like other metastatic disease to the brain, outcome and surviv al in patients without widespread disease is improved by aggressive su rgical and oncological management.