The purpose of this study was to examine the impact of influenza on ho
spitalization in the Netherlands. Two methods were applied to estimate
this effect: (a) regression analysis and (b) comparison of hospitaliz
ation in epidemic years with non-epidemic years. Hospital discharge ra
tes in 1984 - 93 have been considered. The study shows that, during th
e period studied, on average, almost 2700 people were hospitalized for
influenza per annum, and that influenza was diagnosed as the main cau
se for hospitalization in only a fraction of these hospitalizations (3
26: 12%). From an economic perspective, these results imply that the c
ost-effectiveness of vaccination against influenza may be severely und
erestimated when looking only at changes achieved in the number of hos
pitalizations attributed to influenza.